London:
Significant research has been done on the rapid spread of the new type of corona virus “Alpha” which has claimed the lives of millions of people due to its rapid spread.
Last year, in December 2020, British experts announced the discovery of a new strain of the corona virus that was spreading rapidly in the UK. It has become more common than other types. Due to its rapid spread, scientists were amazed at how it finally took control of the world.
Now a new study has revealed the secret to its success. According to research, the alpha type disrupts the initial defenses of the body’s immune system, causing it to rapidly replicate itself in cells.
The results of this new study have not yet been published in a medical journal but have been published online. There have been 233 mutations in the alpha type that differentiate it from other corona viruses and its spread in the UK Genetic testing has since been used to determine how it spreads faster than other species.
Most experts have focused on nine mutations that occur in spike proteins, one of which helps the corona virus to invade cells by hiding, but other scientists have focused on the fact that alpha-type What are the effects on the body’s immune response?
To that end, researchers at London College University and the University of California, Berkeley planted corona viruses in human lung cells and then compared alpha-infected cells with other early types of corona. They discovered that interferon in alpha-infected cells The amount of a protein called nitrite is reduced dramatically, which plays a role in stimulating the immune system.
They also found that the defense genes activated by interferon in these cells were immobilized compared to other types of affected cells. The researchers said that this type of corona did not ring the most important alarm bells of the immune system. In simple words, it makes itself invisible.
The researchers then looked at how the strain managed to keep itself invisible, and for that purpose they examined copies of the corona virus in infected cells. They discovered that other types of alpha-infected cells They make 80 times more copies than ever before, and that’s because of a gene called ORF9B.
